Preventive Role of Soluble Dietary Fiber Against Inflammatory and Life Style Related Diseases

Authors

  • Rizwan Arshad Department of Allied Health Sciences, The University of Chenab, Gujrat, Pakistan
  • Sara Humayun University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
  • Ayesha Jahangeer Department of Allied Health Sciences, The University of Chenab, Gujrat, Pakistan
  • Hafiz Rizwan Sharif Department of Food Science and Technology, Faculty of Science and Technology, The University of Central Punjab, Lahore, Pakistan
  • Muhammad Adnan Nasir Department of Allied Health Sciences, The University of Chenab, Gujrat, Pakistan

Keywords:

Dietary Fiber, Short Chain Fatty Acids (Scfas), Non-Communicable Diseases (Ncds), Cell Signaling Pathways, Healthy Lifestyle, Dietary Guidelines

Abstract

Dietary fiber is broadly recognized to have an effective role in overall health if consumed at around 28g/day for women having 2000 kcal in a day and 36g/day for men having 2600kcal in a day. The burden of non-communicable diseases including constipation, hemorrhoids, colon cancer, obesity, CVD, diabetes, etc. is increasing day by day which could be due to various reasons including lifestyle, dietary patterns, and lack of sufficient amount of dietary fibers in the diet. This review highlights the potential effects of the short chain fatty acids (SCFAs) produced from water soluble dietary fibers against inflammation, colon cancer, colitis, diabetes, and diabetic nephropathy from type 2 diabetes by targeting the short-chain fatty acid receptors such as GPR 43/FFAR3, GPR41/FFAR2, MCT1/SMCT1, histone modification, and cell signaling pathways. SCFAs from different soluble fibers target various GPRs that could be used as a potential therapeutic target for different non-communicable diseases but have not been properly determined as most of the trials are animals based.

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Published

2024-04-30

How to Cite

Rizwan Arshad, Sara Humayun, Ayesha Jahangeer, Hafiz Rizwan Sharif, & Muhammad Adnan Nasir. (2024). Preventive Role of Soluble Dietary Fiber Against Inflammatory and Life Style Related Diseases. RADS Journal of Food Biosciences, 3(1), 29–41. Retrieved from http://jfbs.juw.edu.pk/index.php/jfbs/article/view/28

Issue

Vol. 3 No. 1 (2024): Volume 3 (1) 2024

Section

REVIEW